Aceclofenac Gel

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Aceclofenac Gel Price And Quantity

Minimum Order Quantity 10 Pack

Aceclofenac Gel Trade Information

FOB Port Mumbai sahara airport, Nhavasheva Port (JNPT)
Payment Terms Cash Against Delivery (CAD) Letter of Credit (L/C) Western Union Telegraphic Transfer (T/T) Cash in Advance (CID) Cash Advance (CA)
Supply Ability 10000 Pack Per Week
Delivery Time 7 Days
Sample Available Yes
Sample Policy Contact us for information regarding our sample policy
Packaging Details Alualu/Blister Pack.
Main Export Market(s) Australia North America South America Eastern Europe Western Europe Middle East Central America Asia Africa
Main Domestic Market All India
Certifications USFDA/WHOGMP/GMP

Product Description

Aceclofenac, a anti-inflammatory drug, has been used in the treatment of rheumatoid arthritis and osteoarthritis. In order to decrease the gastric ulcerogenic effects, aceclofenac gels have been developed. This study was conducted to develop a gel formulation of aceclofenac using four types of gelling agents: carbopol, hydroxypropylmethylcellulose(HPMC), carboxymethylcellulose sodium (Na CMC) and sodium alginate. Effect of penetration enhancer (propylene glycol) on the release has been studied. The gels were evaluated for physical appearance, rheological behavior, drug release and stability. The drug release from all gelling agents through a standard cellophane membrane was evaluated using Keshary-Chien diffusion cell. All gels showed acceptable physical properties concerning color, homogeneity, consistency, spreadability and pH value. Among all the gel formulations, carbopol showed superior drug release than followed by Na CMC, HPMC and sodium alginate. Drug release decreased with increase in polymer concentration. Drug release was not linearly proportional with the concentration of penetration enhancer or co-solvents. Stability studies showed that the physical appearance, rheological properties, and drug release remained unchanged upon storage for two months at ambient conditions.

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